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Top 5 Product Review For Nasolabial lines

By November 17, 2020August 4th, 2022Skin

Nasolabial lines, more commonly known as smile lines or laugh lines are naturally occurring grooves on both sides of the nose and separate the cheeks from the upper lip. They are common facial features that should only appear when smiling, hence the name. When not smiling, the smile lines should disappear but with age, they become permanent features of the face and negatively impact facial aesthetics.

Permanent smile lines can be a hassle and may need injectable or surgical intervention, which is pretty scary. This is why we have scoured the internet and reviewed the fie best topical products to reduce smile lines significantly.

Read our in-depth article on what nasolabial lines are; their causes, prevention and surgical treatment here. Image appropriated from Barton, F. E., Jr, & Gyimesi, I. M. (1997). (12)

1. The INKEY List Retinol Serum

$19 USD on Amazon

Value For Money


  • No irritations
  • Works with other products
  • Affordable


  • Too gentle for serious anti-aging benefits
  • Results take a longer time than other products

The INKEY list Retinol Anti-Aging Serum is a powerful retinol cream that smoothens the fine skin lines and texture while also hydrating and brightening the skin to give it a radiant, youthful glow. This cruelty-free product is suitable for all skin types and is free of any parabens, phthalates, and sulfates.

This strong INKEY list concoction is a blend of retinol, squalene, sodium ascorbate, and hyaluronic acid, all ingredients that work together to moisturize the skin and diminish any signs of aging like fine lines and wrinkles, dark spots, and so on.

The main ingredient of this serum is retinol, a Vitamin A derivative best known for its anti-aging properties. In fact, retinol targets and enhances the production of the elastin protein in the skin, which is known to decrease with age resulting in sagging of the skin and reduced skin elasticity (1). This increase in elastin helps tighten the skin to reduce wrinkles and permanent lines on the face.

Moreover, retinol works with the salt of Vitamin C or sodium ascorbate, and together, they increase the skin’s ability to regenerate, an ability usually lost during aging (2). Vitamin C also improves the skin barrier function and promotes collagen synthesis, which further tightens the skin and gives it a young-looking appearance (3).

Another important ingredient of this serum is squalene, an important factor for moisturization of the skin. It has strong anti-oxidant, moisturizing and healing properties for damaged skin and is often medically used to treat dermatological conditions like psoriasis and dermatitis (4).

Overall, this product is a great choice to moisturize, brighten, and tighten your skin to give it a million-dollar glow.

2. Neuropeptide Smoothing Facial Conformer

$325 USD on Amazon

Value For Money


  • Improves the appearance of skin’s elasticity and suppleness
  • Minimizes the appearance of deep lines and wrinkles
  • Reversing the signs of photodamage


  • Has a strong smell
  • Might not work for sensitive skin

The Perricone MD Neuropeptide Facial Conformer is a peptide-rich formula that reduces signs of aging and dry skin significantly. This luxurious product is the result of extensive trials and cutting-edge research by Perricone MD, all of which guarantees age-defying results on your skin.

The Facial Conformer smoothens the skin and gives it a supple texture that makes it worth the price. This luxuriously smooth product is suitable for all skin types and is parabens and sulfate-free. It is a blend of neuropeptides, DMAE, and phospholipids all of which work towards reducing the dullness of the skin and removing permanent and deep facial lines.

DMAE, or 2-dimethylaminoethanol, is a potent ingredient that has several benefits in the cosmetic industry. In a randomized clinical study that was performed with the objective of better understanding the effects of DMAE on aged skin, it was found that it not only reduced the fine lines but also the deep, stubborn facial lines, hence improving the overall appearance of aging skin (5).DMAE also has an acute skin firming effect, resulting in smooth and tightened skin, further removing any signs of aging (5).

Neuropeptides are another important ingredient of this product and they are naturally found in the skin extracellular matrix. They have wound healing properties meaning that they increase the collagen content of the skin, resulting in smooth and spry skin (6)

In general, this product is slightly on the pricier side of the spectrum but is totally worth the hype.

3. Resist Hyaluronic Acid Booster Concentrated Serum

$36 USD on Amazon

Value For Money


  • Revives dehydrated, dull skin
  • Improves the appearance of fine lines & wrinkles
  • Fluid gel texture visibly plumps skin


  • Complicated to use

The Paula’s Choice RESIST Hyaluronic Acid Booster Concentrated serum is a specialized, paraben-free serum suitable for all skin types that work wonders on aged skin. The serum is a smooth and powerful blend of hyaluronic acid, panthenol, and ceramides that revives dull skin and moisturizes the skin to take years off of your face.

Hyaluronic acid, the main ingredient of this product, is a widely known ingredient in the skincare industry due to its strong wound healing properties. Hyaluronic Acid, usually naturally found in the skin, is used in dermatology for its ability to stimulate the synthesis of collagen and growth factors, both of which are important to reverse the effects of aging (7).
Another important ingredient, panthenol works on moisturizing the skin and restoring the skin barrier potential to not only reverse the aging-related damage but also to prevent any further age-associated or photodamage to the skin (8).

All in all, this product is the result of extensive research and is guaranteed to tighten, brighten, and revive your skin like never before.

4. Bioeffect EGF Serum

$165 USD on Amazon

Value For Money


  • Stimulates the natural processes of cell regeneration
  • Reduce the signs of aging
  • Rejuvenate the skin


  • Might make acne worse

The BIOeffect EGF serum is a pure plant-based, anti-aging serum that targets the fine and deep lines of the face along with skin thickness and density to restore the young appearance of the skin. This product contains only seven ingredients and is oil, alcohol, preservatives, and fragrance-free, all the more reason to get it immediately.

The BIOeffect EGF serum’s list of ingredients includes sodium chloride, sodium hyaluronate, and of course, EGF (extracted from barley seeds) among others. The EGF used in the BIOeffect’s serum is a human-like epidermal growth factor that is extracted from bioengineered barley seeds.

EGF or Epidermal Growth Factor is the main ingredient of this product and it is used almost exclusively for its wound healing and collagen enhancing properties, which are quite beneficial in tightening the skin to remove those pestering deep facial lines that just won’t go away (9).

Moreover, EGF works with hyaluronic acid from the sodium hyaluronate to further enhance the skin appearance by reversing the effects of aging and moisturizing it for the supple, young look (10). The combination of wound healing properties of EGF and hyaluronic acid’s hydrating qualities results in a rejuvenated and revived million-dollar skin.

5. SkinMedica TNS Recovery Complex

$220 USD on Amazon

Value For Money


  • Rejuvenates the skin
  • Reduces the appearance of fine lines and wrinkles
  • Enhances skin texture and tone


  • Some users complain about the packaging
  • Might not work for some people

The SkinMedica TNS Recovery Complex is a luxurious gel that enhances the skin texture and reduces brown and red spots on the skin along with lines and wrinkles, indicative of aged or photodamaged skin. SkinMedica uses its own blend of patented growth factors, collagen, matrix proteins, and antioxidants aptly named Tissue Nutrient Solution (TNS) as the main ingredient in almost all of their products.

The concentrated TNS enriched serum is a blend of human fibroblast conditioned media, coumarin, and caprylyl glycol and is guaranteed to rejuvenate your skin and remove all signs of aging from your skin.
The human fibroblast conditioned media is the key ingredient in the reversal of age-associated and UV rays associated-damage to the skin. In fact, the conditioned media has wound healing and collagen-stimulating mediators, to heal and prevent any damage to the skin (11).

All the growth factors and matrix proteins, along with collagen basically work together to tighten the skin while also improving the skin texture and pigmentation. The SkinMedica product is another slightly expensive product but their TNS formula makes the product worth each and every penny.


  1. Rossetti, D et al. “A novel anti-ageing mechanism for retinol: induction of dermal elastin synthesis and elastin fibre formation.” International journal of cosmetic science vol. 33,1 (2011): 62-9. doi:10.1111/j.1468-2494.2010.00588.x
  2. Wójcik, Aneta et al. “Influence of the complex of retinol-vitamin C on skin surface lipids.” Journal of cosmetic dermatology vol. 14,2 (2015): 92-9. doi:10.1111/jocd.12140
  3. Pullar, Juliet M et al. “The Roles of Vitamin C in Skin Health.” Nutrients vol. 9,8 866. 12 Aug. 2017, doi:10.3390/nu9080866
  4. Wołosik, Katarzyna et al. “The importance and perspective of plant-based squalene in cosmetology.” Journal of cosmetic science vol. 64,1 (2013): 59-66.
  5. Grossman, Rachel. “The role of dimethylaminoethanol in cosmetic dermatology.” American journal of clinical dermatology vol. 6,1 (2005): 39-47. doi:10.2165/00128071-200506010-00005
  6. Kiya, Koichiro, and Tateki Kubo. “Neurovascular interactions in skin wound healing.” Neurochemistry international vol. 125 (2019): 144-150. doi:10.1016/j.neuint.2019.02.014
  7. Keen, Mohammad Abid. “Hyaluronic Acid in Dermatology.” Skinmed vol. 15,6 441-448. 1 Dec. 2017
  8. Stettler, Hans et al. “A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora.” The Journal of dermatological treatment vol. 28,2 (2017): 173-180. doi:10.1080/09546634.2016.1214235
  9. Shen, Congcong et al. “Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing.” International journal of molecular medicine vol. 39,4 (2017): 949-959. doi:10.3892/ijmm.2017.2911
  10. Draelos, Zoe Diana. “The Effect of a Combination of Recombinant EGF Cosmetic Serum and a Crosslinked Hyaluronic Acid Serum as Compared to a Fibroblast-Conditioned Media Serum on the Appearance of Aging Skin.” Journal of drugs in dermatology : JDD vol. 15,6 (2016): 738-41.
  11. Maarof, Manira et al. “Proteomic Analysis of Human Dermal Fibroblast Conditioned Medium (DFCM).” The protein journal vol. 37,6 (2018): 589-607. doi:10.1007/s10930-018-9800-z
  12. Barton, F. E., Jr, & Gyimesi, I. M. (1997). Anatomy of the nasolabial fold. Plastic and reconstructive surgery100(5), 1276–1280.
Dr Mingma Sony

Mingma Sony MD is a medical practitioner currently working hard to provide health-related services to people in need. With a medical degree completed at a young age, she is also a valued medical writer and editor at QOVES Studio. She writes medical articles with impeccable accuracy owing to her vast medical knowledge and thorough research.